In a harrowing world where shadows vanish and memories fade, 'The Book of M' follows Ory and his wife, Max, as they grapple with a bizarre plague that steals the essence of their being. After Max's shadow disappears, heralding the loss of her recollections, she flees, aware of the peril she poses to Ory as her mind unravels. Ory, driven by love and determination, embarks on a quest through a landscape marred by chaos and war to find Max before her identity is lost completely. Their paths intersect with mystic cults, combative forces, and the glimmer of a cure in the south, all while questioning the significance of memory and humanity.