Spanning across two eras, 'The Great Believers' explores the impact of the AIDS crisis in Chicago during the 1980s and its reverberations in contemporary Paris. Yale Tishman, working for an art gallery, finds his world crumbling as friends succumb to the epidemic. Meanwhile, Fiona, the sister of one of Yale's deceased friends, is in Paris decades later, confronting the long-lasting effects of AIDS on her family as she searches for her estranged daughter. Their interwoven narratives tell a tale of loss, kinship, and the search for redemption amidst catastrophe.