"Of One Blood" is an early 20th-century novel by Pauline E. Hopkins that intricately combines the elements of science fiction with Gothic horror and the occult. Set against a background of racial tensions and the complexities of Black identity and heritage, the narrative follows Reuel Briggs, a mixed-race medical student who passes for white. When he saves the mysterious Dianthe Lusk from near death using mesmerism, his life begins to spiral into a series of unforeseen events. An archaeological expedition leads him to a forgotten Ethiopian city, Telassar, imbued with advanced technologies and ancient powers. Amidst the grandeur and conspiracy, Reuel confronts not only his true lineage but also the zeitgeist of a race marked by a history of slavery and prejudice. Pauline E. Hopkins, through this novel, not only captures the struggles of racial identity but also pioneers a voice for the African American science fiction genre.