Lexie Sinclair yearns for a life beyond the confines of her parents' strict, rural upbringing. Yearning for the pulsating heart of 1950s London, she seizes her chance with Innes Kent, a magnetic figure who introduces her to the bohemian art scene of Soho. As she forges her path as a reporter, embracing art and independence, Lexie's life takes an unexpected turn with single motherhood. Years later, Elina, a new mother herself, struggles with postpartum amnesia, while her partner Ted is haunted by resurfacing memories that hint at a mysterious connection with Lexie's past. 'The Hand That First Held Mine' is a mesmerizing exploration of love, art, and the indelible marks we leave on each other's lives.