After Annie tells the moving story of a family and a close friend who must find a path to healing after the sudden death of Annie Brown, the woman who anchored their lives. Her husband Bill grapples with overwhelming grief, and Annemarie, Annie's best friend, faces the resurgence of personal demons. Ali, Annie's eldest daughter, prematurely takes on adult responsibilities, supporting her brothers and helping her father. Throughout the year that follows, the power of Annie's indomitable spirit, her wisdom, and humor continue to guide them, proving that the bond of love is stronger than death. As they each navigate this painful chapter, they discover that adversity can forge new strengths and that loved ones, though gone, can still shape our lives in beautiful and lasting ways.