In the sleepless city of New York, Cleo, a British painter on the verge of visa expiration, meets Frank, a man twenty years her senior with a life of success and excess. An impulsive marriage between the two leads to life-altering consequences for them and their circle. Cleo's best friend grapples with gender identity while Frank's sister turns to sugar daddy dates after being financially cut off. 'Cleopatra and Frankenstein' examines the trials of marriage and mental illness, the shockwaves of impetuous decisions, and the compelling journey of flawed yet fascinating individuals.